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Endocrine combined therapy of breast cancer
周 莉;?张百红
中国人民解放军联勤保障部队第九四〇医院肿瘤科,甘肃 兰州 730050
Zhou Li;?Zhang Baihong
Department of Oncology,No.940 Hospital of Joint Logistics Support Force of People's Liberation Army,Gansu Lanzhou 730050,China.
breast neoplasm;?estrogen receptors;?endocrine therapy
Endocrine therapies that target the hormone receptors-positive breast cancer have substantial activity,yet the development of resistant to therapy is inevitable.The era of endocrine combined therapy of breast cancer has arrived.Combinational therapeutics can overcome resistance and improve clinical benefit.Combinational strategies include adding inhibitors targeting growth factors,angiogenesis,phosphoinositide 3-kinase (PI3K),mammalian target of rapamycin (mTOR),cyclin-dependent kinase 4/6,human epidermal growth factor receptor 2,or targeted epigenetic agents to endocrine therapy.Herein,we review the current study and new drugs of endocrine combined therapy of breast cancer.


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更新日期/Last Update: 1900-01-01