|本期目录/Table of Contents|

ATF4与RPL41在输卵管癌组织中的表达及其临床意义

《现代肿瘤医学》[ISSN:1672-4992/CN:61-1415/R]

期数:
2019年20期
页码:
3690-3694
栏目:
论着(妇科肿瘤)
出版日期:
2019-09-08

文章信息/Info

Title:
Expression and clinical significance of ATF4 and RPL41 proteins in primary fallopian tube carcinoma
作者:
汤丽红;?马宁耶;?王 岩;?余 璐;?柳 祎;?焦伊胜
中国医科大学附属盛京医院妇产科,辽宁 沈阳 110004
Author(s):
Tang Lihong;?Ma Ningye;?Wang Yan;?Yu Lu;?Liu Yi;?Jiao Yisheng
Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China.
关键词:
ATF4;?RPL41;?输卵管癌;?免疫组织化学
Keywords:
ATF4;?RPL41;?primary fallopian tube carcinoma;?immunohistochemistry
分类号:
R737.32
DOI:
10.3969/j.issn.1672-4992.2019.20.032
文献标识码:
A
qq自动领红包软件:
目的:检测ATF4与RPL41在输卵管癌组织中的表达情况,并探讨其表达特点以及临床意义。方法:采用免疫组化SP法检测输卵管癌标本50例和正常输卵管标本26例中ATF4与RPL41的表达情况,并分析其与输卵管癌临床病理参数之间的关系。结果:ATF4在输卵管癌组织中阳性表达率为86.0%,明显高于正常输卵管组织中的38.5%,差异具有统计学意义(P<0.001);RPL41在正常输卵管组织中阳性表达率为80.8%,明显高于输卵管癌组织中的38.0%,差异有统计学意义(P=0.001<0.05)。且ATF4与RPL41在输卵管癌组织中的表达有相关性(r=-0.296,P=0.037<0.05)。结论:ATF4与RPL41可能在输卵管癌的发生中起重要作用,高表达的ATF4对诊断原发性输卵管癌可能有指导意义。
Abstract:
Objective:To explore the expression of ATF4 and RPL41 protein in primary fallopian tube carcinoma and their clinical significance.Methods:The expression of ATF4 and RPL41 protein in 50 cases of fallopian tube carcinoma and 26 cases of normal fallopian tube were evaluated by SP immunohistochemistry,and to analyze their correlations with clinical pathological factors in primary fallopian tube carcinoma(PFTC).Results:The positive expression rate of ATF4 in PFTC(86.0%) was higher than that in normal fallopian tube(38.5%),which showed significant difference(P<0.001).The positive expression rate of RPL41 in normal fallopian tube tissues (80.8%)was higher than that in PFTC(38.0%),which showed significant difference(P=0.001<0.05).There was a significant correlation between the expression of ATF4 and RPL41 in primary fallopian tube carcinoma(r=-0.296,P=0.037<0.05).Conclusion:ATF4 and RPL41 play important roles in the occurrence of primary fallopian tube carcinoma,and the overexpression of ATF4 may guide the diagnosis of primary fallopian tube carcinoma.

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备注/Memo

备注/Memo:
National Natural Science Foundation of China(No.81272873);国家自然科学基金(编号:81272873)
更新日期/Last Update: 1900-01-01